Tuesday, 26 February 2019: Amnion or amniotic membrane is the innermost layer of the placenta. It comprises an avascular stromal matrix and thick basement membrane. Its transplantation has been used as a graft in many surgical procedures. It consists of pain reduction, anti-inflammatory, and wound healing properties.
Amniotic membrane contains growth factors such as basic fibroblast growth factor (bFGF), epidermal growth Factor (EGF), transforming growth factors (TGFs), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF), and nerve growth factor (NGF), which aid in wound healing. These products are being widely used in the management of chronic wounds, treatment of venous, surgeries, ophthalmology, pressure, and diabetic foot ulcers.
Utilization in Reconstructive Surgeries can Boost Demand
Amniotic membrane finds applications in surgical wounds, ophthalmology, and others. These products are increasingly used in ophthalmic surgeries for quick recovery and reducing inflammation. It is preserved in cryopreserved amniotic membranes with its biological and histological properties. So, these products are being increasingly used in ocular surgeries for faster recovery and reduced inflammation of the eye. For instance, BioStem Life Sciences has recently introduced placental-derived tissue products for orthopedic ophthalmology, and advanced wound care. They are named such as a chorion-free amniotic tissue allograft membrane, an amniotic tissue allograft flowable matrix, and an extracellular amniotic membrane allograft for ocular repair, an amniotic tissue allograft membrane with chorion layer.
The amnion is utilized in reconstructive surgeries to reduce scarring and boost healing. High demand for cosmetic surgeries is expected to drive the segment growth in the coming years. As per information provided by American Society of Plastic Surgeons, in 2017, more than 17.5 million surgical cosmetic procedures were achieved in the U.S. This also concludes that number of surgeries for improving astatic appeal has increased.
Dehydrated amniotic membranes, such as FlÅGraft, AmnioFix, PalinGen, and AmbioDisk, are preferred in reconstruction surgeries, and to treat surgical wounds, and venous and pressure leg ulcers. Utilization of these products in burn injury treatments provide epithelialization, which is an essential component for wound healing. It also enables relaxed movements of the injured area. These products are inexpensive as compared to allografts and xenografts. This is also expected to drive the segment growth.
Market Overview
According to a report published by Grand View Research, Inc.; the global amniotic membrane market is expected to accomplish a valuation of around USD 5.81 billion by 2025. Growing R&D efforts related to stem cells and regenerative medicines and growing number of surgical procedures all over the world due to burn cases and accidents can propel the market during the forecast period (2014 to 2025). Growing awareness about these products has increased the number of transplants, which requires tissue-based products. This has also increased the number of placental donations, thereby driving the market growth.
North America was estimated as largest markets in 2017. In terms of revenue, Europe was the second leading markets in the same year and expected to expand at a CAGR of 11.9% during the forecast period. This can be ascribed to high occurrence of chronic diseases and surgical procedures. Asia Pacific is also expected to exhibit high CAGR on account of improving economic condition and increasing efforts for medical research. Numerous international companies are also investing heavily in the region.
Key companies operating in the amniotic membrane market include MiMedx Group, Inc.; Human Regenerative Technologies; Skye Biologics, Inc.; Organogensis, Inc. and Amniox Medical, Inc.
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